Evidence and methods
Publications Research articles and methods from the Kalderon Lab, organized for direct access to the primary record.
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All Follicle stem cells Hedgehog Methods Reviews
Featured papers 2 papers + −
01
Genetics · 2026
Positional and proliferative signals guide common somatic precursors toward escort-cell, follicle-stem-cell, and follicle-cell outcomes during pupal ovary development.
Links & citation for Regulation of somatic stem cell development through positional and proliferative signals during Drosophila melanogaster pupal ovary development resembles the framework governing adult stem cell behavior + − Copy citation
02
PLOS Biology · 2025
Multiple Fused target sites promote Ci activation principally by altering Ci–Ci interactions, without requiring full Suppressor of Fused dissociation.
Links & citation for Hedgehog-stimulated phosphorylation at multiple sites activates Ci by altering Ci–Ci interfaces without full Suppressor of Fused dissociation + − Jump to year 2026 2025 2023 2022 2021 2020 2018 2017 2015 2014 2012 2011 2009 2007 2006 2005 2002 2001 2026 Follicle stem cells
Rachel Misner, Amy Reilein, Helen V. Kogan, Daniel Kalderon
Genetics
Links & citation for Regulation of somatic stem cell development through positional and proliferative signals during Drosophila melanogaster pupal ovary development resembles the framework governing adult stem cell behavior + − Copy citation
2025 Hedgehog
Hoyon Kim, Jamie C. Little, Jiashen Li, Bryna Patel, Daniel Kalderon
PLOS Biology
Links & citation for Hedgehog-stimulated phosphorylation at multiple sites activates Ci by altering Ci–Ci interfaces without full Suppressor of Fused dissociation + − 2023 Follicle stem cells
Zhi Dong, Lan Pang, Zhiguo Liu, Yifeng Sheng, Xiaoping Li, Xavier Thibault, Amy Reilein, Daniel Kalderon, Jianhua Huang
BMC Biology
Links & citation for Single-cell expression profile of Drosophila ovarian follicle stem cells illuminates spatial differentiation in the germarium + − Follicle stem cells
David Melamed, Aaron Choi, Amy Reilein, Simon Tavaré, Daniel Kalderon
PLOS Genetics
Links & citation for Spatial regulation of Drosophila ovarian Follicle Stem Cell division rates and cell cycle transitions + − 2022 Methods Review
Daniel Kalderon
Stem Cell Reviews and Reports
Links & citation for Investigating Adult Stem Cells Through Lineage analyses + − 2021 Follicle stem cells
Amy Reilein, Helen V. Kogan, Rachel Misner, Karen Sophia Park, Daniel Kalderon
eLife
Links & citation for Adult stem cells and niche cells segregate gradually from common precursors that build the adult Drosophila ovary during pupal development + − 2020 Hedgehog
Jamie C. Little, Elisa Garcia-Garcia, Amanda Sul, Daniel Kalderon
eLife
Links & citation for Drosophila hedgehog can act as a morphogen in the absence of regulated Ci processing + − Follicle stem cells
David Melamed, Daniel Kalderon
eLife
Links & citation for Opposing JAK–STAT and Wnt signaling gradients define a stem cell domain by regulating differentiation at two borders + − 2018 Follicle stem cells Methods
Karen Sophia Park, Dorothea Godt, Daniel Kalderon
Journal of Visualized Experiments
Links & citation for Dissection and Staining of Drosophila Pupal Ovaries + − Follicle stem cells
Amy Reilein, David Melamed, Simon Tavaré, Daniel Kalderon
Proceedings of the National Academy of Sciences
Links & citation for Division-independent differentiation mandates proliferative competition among stem cells + − Follicle stem cells Methods
Amy Reilein, Elisa Cimetta, Nina M. Tandon, Daniel Kalderon, Gordana Vunjak-Novakovic
Nature Protocols
Links & citation for Live imaging of stem cells in the germarium of the Drosophila ovary using a reusable gas-permeable imaging chamber + − 2017 Follicle stem cells
Amy Reilein, David Melamed, Karen Sophia Park, Ari Berg, Elisa Cimetta, Nina Tandon, Gordana Vunjak-Novakovic, Sarah Finkelstein, Daniel Kalderon
Nature Cell Biology
Links & citation for Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signaling + − Hedgehog
Elisa Garcia-Garcia, Jamie C. Little, Daniel Kalderon
Genetics
Links & citation for The Exon Junction Complex and Srp54 contribute to Hedgehog signaling via ci RNA splicing in Drosophila melanogaster + − Follicle stem cells Hedgehog
Jianhua Huang, Amy Reilein, Daniel Kalderon
Development
Links & citation for Yorkie and Hedgehog independently restrict BMP production in escort cells to permit germline differentiation in the Drosophila ovary + − 2015 Hedgehog
Eva V. Zadorozny, Jamie C. Little, Daniel Kalderon
Development
Links & citation for Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila + − 2014 Follicle stem cells Hedgehog
Jianhua Huang, Daniel Kalderon
Journal of Cell Biology
Links & citation for Coupling of Hedgehog and Hippo pathways promotes stem cell maintenance by stimulating proliferation + − 2012 Follicle stem cells
Zhu A. Wang, Jianhua Huang, Daniel Kalderon
Nature Communications
Links & citation for Drosophila follicle stem cells are regulated by proliferation and niche adhesion as well as mitochondria and ROS + − Follicle stem cells
Cynthia Vied, Amy Reilein, Natania S. Field, Daniel Kalderon
Developmental Cell
Links & citation for Regulation of stem cells by intersecting gradients of long-range niche signals + − 2011 Hedgehog
Qianhe Zhou, Daniel Kalderon
Developmental Cell
Links & citation for Hedgehog activates Fused through phosphorylation to elicit a full spectrum of pathway responses + − Hedgehog
Steven A. Marks, Daniel Kalderon
Development
Links & citation for Regulation of mammalian Gli proteins by Costal 2 and PKA in Drosophila reveals Hedgehog pathway conservation + − 2009 Follicle stem cells
Zhu A. Wang, Daniel Kalderon
Proceedings of the National Academy of Sciences
Links & citation for Cyclin E-dependent protein kinase activity regulates niche retention of Drosophila ovarian follicle stem cells + − Follicle stem cells Hedgehog
Cynthia Vied, Daniel Kalderon
Development
Links & citation for Hedgehog-stimulated stem cells depend on non-canonical activity of the Notch co-activator Mastermind + − 2007 Hedgehog
Margery G. Smelkinson, Qianhe Zhou, Daniel Kalderon
Developmental Cell
Links & citation for Regulation of Ci-SCFSlimb binding, Ci proteolysis, and Hedgehog pathway activity by Ci phosphorylation + − 2006 Hedgehog
Qianhe Zhou, Sergey Apionishev, Daniel Kalderon
Genetics
Links & citation for The contributions of protein kinase A and smoothened phosphorylation to hedgehog signal transduction in Drosophila melanogaster + − 2005 Hedgehog
Sergey Apionishev, Natalya M. Katanayeva, Steven A. Marks, Daniel Kalderon, Andrew Tomlinson
Nature Cell Biology
Links & citation for Drosophila Smoothened phosphorylation sites essential for Hedgehog signal transduction + − 2002 Hedgehog
Mary Ann Price, Daniel Kalderon
Cell
Links & citation for Proteolysis of the Hedgehog signaling effector Cubitus interruptus requires phosphorylation by Glycogen Synthase Kinase 3 and Casein Kinase 1 + − 2001 Follicle stem cells Hedgehog
Yan Zhang, Daniel Kalderon
Nature
Links & citation for Hedgehog acts as a somatic stem cell factor in the Drosophila ovary + −