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Studying spatial regulation of Drosophila follicle stem cells and Hedgehog signal transduction.
Research question
In Drosophila ovaries and wing discs, the Kalderon Lab studies how spatial signals regulate follicle stem-cell division and differentiation, and how Hedgehog-dependent phosphorylation activates the Ci transcription factor.
Microscopy paired with its BioVision reconstruction. The meshes are tracked segmented regions; source contour colors can repeat and do not identify cell type.
Source-paired BioVision reconstruction and lossless maximum-intensity microscopy projection at 31 biological timepoints, sampled every 531 seconds (8.85 min).
The orthographic 3D view shares the microscopy field. Biological time advances through the paired timepoints while camera rotation, pan, and zoom remain independent. Frame-to-frame movement is shown without artificial stabilization.
Research programs
Follicle stem cells occupy different anterior–posterior positions, exchange locations, and divide at different rates within one dynamic community. The lab studies how spatial signals coordinate division and differentiation across that community.
Open research chapter 02 / Hedgehog signalingHedgehog signals act through Smoothened and Fused to change Ci activity. The lab tests how phosphorylation and protein interactions convert pathway input into transcriptional output.
Open research chapterFeatured findings
01
Positional and proliferative signals guide common somatic precursors toward escort-cell, follicle-stem-cell, and follicle-cell outcomes during pupal ovary development.
02
Multiple Fused target sites promote Ci activation principally by altering Ci–Ci interactions, without requiring full Suppressor of Fused dissociation.
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